PUERARIA MIRIFICA. MIRACLE SCIENCE.

PUERARIA MIRIFICA. MIRACLE SCIENCE.™

Estriol vs. Estradiol:
Effects, Side Effects, and Alternatives

Estriol vs. Estradiol:
Effects, Side Effects, and Alternatives

Both estriol and estradiol are female sex hormones (estrogens) that women take to relieve menopause symptoms, support their youthfulness, and delay aging. However, if you’d have to choose between the two, which would be a better pick between estriol vs estradiol?

 

To find out, let’s go through a quick recap on estrogens in the first place.

 

This article will focus on estradiol and estriol because the first one, estrone, is deemed the “unhealthy” estrogen. High amounts of E1 are linked to moodiness, bloating, and increased appetite. Estrone metabolites are also linked to breast cancer. That’s why this form is not used in estrogen replacement therapy.

This article will focus on estradiol and estriol because the first one, estrone, is deemed the “unhealthy” estrogen. High amounts of E1 are linked to moodiness, bloating, and increased appetite. Estrone metabolites are also linked to breast cancer. That’s why this form is not used in estrogen replacement therapy.

PHYTOESTROGENS GROCERY LIST

PHYTOESTROGENS GROCERY LIST

We designed this infographic to easier provide you an overview of the best foods for hormone imbalances.

Download it by entering your email below (we will send it to your email), print it out, tape it to your fridge, or bring it to the supermarket when you do your weekly grocery shopping.

Estrogen 101

Estrogen 101

Estrogen is a hormone, the primary function of which is to promote the maintenance of female characteristics of the body. It's is one of the primary female hormones linked to sexual and reproductive development.

 

The human body produces three different types of estrogen: Estrone (E1), Estradiol (E2), and Estriol (E3).

 

This article will focus on estradiol and estriol because the first one, estrone, is deemed the “unhealthy” estrogen. High amounts of E1 are linked to moodiness, bloating, and increased appetite. Estrone metabolites are also linked to breast cancer. That’s why this form is not used in estrogen replacement therapy.

 

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Estriol

Estriol

This is the “weakest” form of estrogen.

 

Compared to conventionalpharmaceuticalestrogens that typically make use of just estradiol, this is generally safer to use.

 

Initially, it was deemed insignificant because of the weak estrogenic activity. However, over time, it has proven to be of use in treating various conditions.

 

Effects

Effects

Studies have shown that it is highly effective in mitigating symptoms of menopause. In particular, it can reduce occurrences of hot flashes and vaginal dryness.

 

Ironically, it being the weaker form may be its strongest suit because topical formulations of estriol do not increase the risk of cancers associated with hormonal therapy such as breast or endometrium cancer.

 

Estriol is great for the skin and mucous membranes, and its topical application can help increase collagen and hydrate cells. And thus, it’s very effective in menopausal women who deal with painful intercourse due to physiological changes like vaginal dryness and vaginal atrophy.

 

Recent research indicates that estriol has beneficial effects on bone mineral density. Estrogen has a role in bone formation, and thus many elderly women suffer from problems like osteoporosis which predisposes them to fractures even after trivial trauma.

 

Interestingly in the same study that showed its link to better bone mineral density, it was also found that estriol may lower total cholesterol levels and enhance High-Density Lipoprotein (HDL) levels (the "good" cholesterol).

 

While more research is necessary in this regard, the findings so far suggest that treatment with estriol is associated with a decrease in blood pressure.

 

The above findings suggest that estriol may have beneficial effects on cardiovascular health.

 

It is also beneficial for postmenopausal women who suffer from recurrent urinary tract infections. A randomized controlled trial found that this form of estrogen can improve symptoms of urinary incontinence and can reduce the recurrence of UTI.

 

Dosage Forms

Dosage Forms

It is available in various formulations such as tablets, creams, and suppositories over-the-counter.

 

Side Effects

Side Effects

Side effects include weight gain, migraine, edema, breast tenderness and pain, fatigue, bloating, changes in menstrual bleeding, and upper respiratory tract infections.

 

Additionally, it can cause spotting and periods. Those who take it may also experience moodiness.

 

Estradiol

Estradiol

Estradiol is the most potent form of estrogen that is typically used in hormone replacement therapy (HRT).

 

It is available in the form of oral tablets, transdermal gels, creams or, patches. It is also available in the form of injections.

 

Since its primary use is to reduce menopausal symptoms that manifest in the vagina, such as dryness and itching, it can be administered locally.

 

Effects

Effects

Similar to estriol, it is excellent in improving bone mineral density and preventing urinary tract infections.

 

It can help in relieving menopausal symptoms such as night sweats and hot flashes.

 

It also enhances vaginal secretions and thus lubrication during sexual intercourse.

 

Additionally, research has also shown that both (estriol and estradiol) are beneficial in maintaining neurological health.

 

Dosage Forms

Dosage Forms

It is also available in various formulations such as tablets, creams, transdermal patches, and suppositories over-the-counter.

 

Side Effects

Side Effects

Just like estriol, it may cause weight gain and breast tenderness. Other side effects include bloating, migraine, edema, breast pain, fatigue, changes in menstrual bleeding, and upper respiratory tract infections.

 

Estradiol promotes growth in specific areas, such as the breast tissue and the lining of the uterus. Thus, if taken without estriol, it may be associated with a higher risk of uterine or breast cancer.

 

When taken orally or as an injection, more estrogen is absorbed, leading to a higher risk of side effects .

 

Estriol vs. Estradiol: A Comparison

Estriol vs Estradiol: A Comparison

Similarities

Similarities

  • Estriol and estradiol are bioidentical.
  • They are both prescribed for vaginal menopausal symptoms such as atrophy and dryness, as well as postmenopausal osteoporosis as a part of hormonal replacement therapy.
  • Pregnancy is a common contraindication for both.
  • Both are metabolized in the liver by CYP3A4 enzymes.

    o Thus, their efficiency is reduced when given along with
    phenytoin, rifampin, carbamazepine, dexamethasone (CYP3A4 inducers).

    o Consequently, their toxicity increases when administered along with erythromycin, clarithromycin, ketoconazole, itraconazole, and cimetidine (CYP3A4 inhibitors).

 

Differences

Differences

Their difference lies in potency and safety. Estriol is deemed weaker, but safer, compared to estradiol.

 

Estradiol is more potent in growing tissue, such as breast and the uterus.

 

While both are available in the form of oral tablets, vaginal creams, and suppositories, only estradiol is available as transdermal patches.

 

Nonetheless, to get the most out of estradiol without the side effects, doctors will typically recommend balancing your intake with estriol.

 

The Safest Alternative

The Safest Alternative

If you’re looking for the safest way to increase estrogen and you have no access to pharmaceutical options, there is another option: go the all-natural way.

 

There are specific types of food that can boost compounds that have the same effect as estrogen in your bloodstream. These estrogen boosters are rich in phytoestrogens, which are plant-derived estrogens that mimic the action of endogenous estrogen in your body. These include food such as soybeans, oats, and flaxseeds.

 

Other sources include supplements that make use of active ingredients sourced from plants such as Puerariamirifica. The phytoestrogens from P. mirifica will produce milder side effects, resulting in a safer yet effective estrogen supplement.

 

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Estriol and estradiol help improve the quality of life in elderly women by relieving their various menopausal symptoms and reducing the risk of osteoporosis.

Estriol and estradiol help improve the quality of life in elderly women by relieving their various menopausal symptoms and reducing the risk of osteoporosis.

PUERARIA MIRIFICA
WHAT DOES THE RESEARCH SAY?

Conclusion

Conclusion

Estriol and estradiol help improve the quality of life in elderly women by relieving their various menopausal symptoms and reducing the risk of osteoporosis.

 

Natural alternatives are available as phytoestrogens in multiple dietary substances like soybeans and oats, as well as in the form of supplements derived from Puerariamirifica.

 

We recommend that you choose your treatment modality under the guidance of a licensed health care professional. Your doctor can help you sort out which hormone in the estriol vs estradiol matter would be better for your case, and even recommend you an optimal natural alternative!

 

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*These statements have not been evaluated by the FDA. Products are not intended to diagnose, treat, cure or prevent any disease.

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication or have a medical condition.

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