Estriol vs. Estradiol:
Effects, Side Effects, and Alternatives
Estriol vs. Estradiol:
Effects, Side Effects, and Alternatives
Both estriol and estradiol are female sex hormones (estrogens) that women take to relieve menopause symptoms, support their youthfulness, and delay aging. However, if you’d have to choose between the two, which would be a better pick between estriol vs estradiol?
To find out, let’s go through a quick recap on estrogens in the first place.
This article will focus on estradiol and estriol because the first one, estrone, is deemed the “unhealthy” estrogen. High amounts of E1 are linked to moodiness, bloating, and increased appetite. Estrone metabolites are also linked to breast cancer. That’s why this form is not used in estrogen replacement therapy.
This article will focus on estradiol and estriol because the first one, estrone, is deemed the “unhealthy” estrogen. High amounts of E1 are linked to moodiness, bloating, and increased appetite. Estrone metabolites are also linked to breast cancer. That’s why this form is not used in estrogen replacement therapy.
PHYTOESTROGENS GROCERY LIST
PHYTOESTROGENS GROCERY LIST
Table of Contents
- 1. NATURAL VASODILATORS GROCERY LIST
- 2. Why Natural Vasodilators?
- 3. Blood Flow Supporting Foods
- Cayenne Pepper and Chili
- Citrus Fruits
- Dark Chocolate and Raw Caca
- Ginger
- Black Ginger
- Garlic
- Watermelon
- Tea
- Pomegranate
- Walnuts, Pistachios, Peanuts and Most Other Nuts
- Red Wine and Grapes
- Beetroot
- Spinach
- Raw Honey
- Kale
- Shrimp
Estrogen 101
Estrogen 101
Estrogen is a hormone, the primary function of which is to promote the maintenance of female characteristics of the body. It's is one of the primary female hormones linked to sexual and reproductive development.
The human body produces three different types of estrogen: Estrone (E1), Estradiol (E2), and Estriol (E3).
This article will focus on estradiol and estriol because the first one, estrone, is deemed the “unhealthy” estrogen. High amounts of E1 are linked to moodiness, bloating, and increased appetite. Estrone metabolites are also linked to breast cancer. That’s why this form is not used in estrogen replacement therapy.
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Estriol
Estriol
This is the “weakest” form of estrogen.
Compared to conventionalpharmaceuticalestrogens that typically make use of just estradiol, this is generally safer to use.
Initially, it was deemed insignificant because of the weak estrogenic activity. However, over time, it has proven to be of use in treating various conditions.
Effects
Effects
Studies have shown that it is highly effective in mitigating symptoms of menopause. In particular, it can reduce occurrences of hot flashes and vaginal dryness.
Ironically, it being the weaker form may be its strongest suit because topical formulations of estriol do not increase the risk of cancers associated with hormonal therapy such as breast or endometrium cancer.
Estriol is great for the skin and mucous membranes, and its topical application can help increase collagen and hydrate cells. And thus, it’s very effective in menopausal women who deal with painful intercourse due to physiological changes like vaginal dryness and vaginal atrophy.
Recent research indicates that estriol has beneficial effects on bone mineral density. Estrogen has a role in bone formation, and thus many elderly women suffer from problems like osteoporosis which predisposes them to fractures even after trivial trauma.
Interestingly in the same study that showed its link to better bone mineral density, it was also found that estriol may lower total cholesterol levels and enhance High-Density Lipoprotein (HDL) levels (the "good" cholesterol).
While more research is necessary in this regard, the findings so far suggest that treatment with estriol is associated with a decrease in blood pressure.
The above findings suggest that estriol may have beneficial effects on cardiovascular health.
It is also beneficial for postmenopausal women who suffer from recurrent urinary tract infections. A randomized controlled trial found that this form of estrogen can improve symptoms of urinary incontinence and can reduce the recurrence of UTI.
Dosage Forms
Dosage Forms
It is available in various formulations such as tablets, creams, and suppositories over-the-counter.
Side Effects
Side Effects
Side effects include weight gain, migraine, edema, breast tenderness and pain, fatigue, bloating, changes in menstrual bleeding, and upper respiratory tract infections.
Additionally, it can cause spotting and periods. Those who take it may also experience moodiness.
Estradiol
Estradiol
Estradiol is the most potent form of estrogen that is typically used in hormone replacement therapy (HRT).
It is available in the form of oral tablets, transdermal gels, creams or, patches. It is also available in the form of injections.
Since its primary use is to reduce menopausal symptoms that manifest in the vagina, such as dryness and itching, it can be administered locally.
Effects
Effects
Similar to estriol, it is excellent in improving bone mineral density and preventing urinary tract infections.
It can help in relieving menopausal symptoms such as night sweats and hot flashes.
It also enhances vaginal secretions and thus lubrication during sexual intercourse.
Additionally, research has also shown that both (estriol and estradiol) are beneficial in maintaining neurological health.
Dosage Forms
Dosage Forms
It is also available in various formulations such as tablets, creams, transdermal patches, and suppositories over-the-counter.
Side Effects
Side Effects
Just like estriol, it may cause weight gain and breast tenderness. Other side effects include bloating, migraine, edema, breast pain, fatigue, changes in menstrual bleeding, and upper respiratory tract infections.
Estradiol promotes growth in specific areas, such as the breast tissue and the lining of the uterus. Thus, if taken without estriol, it may be associated with a higher risk of uterine or breast cancer.
When taken orally or as an injection, more estrogen is absorbed, leading to a higher risk of side effects .
Estriol vs. Estradiol: A Comparison
Estriol vs Estradiol: A Comparison
Similarities
Similarities
- Estriol and estradiol are bioidentical.
- They are both prescribed for vaginal menopausal symptoms such as atrophy and dryness, as well as postmenopausal osteoporosis as a part of hormonal replacement therapy.
- Pregnancy is a common contraindication for both.
-
Both are metabolized in the liver by CYP3A4 enzymes.
o Thus, their efficiency is reduced when given along with
phenytoin, rifampin, carbamazepine, dexamethasone (CYP3A4 inducers).
o Consequently, their toxicity increases when administered along with erythromycin, clarithromycin, ketoconazole, itraconazole, and cimetidine (CYP3A4 inhibitors).
Differences
Differences
Their difference lies in potency and safety. Estriol is deemed weaker, but safer, compared to estradiol.
Estradiol is more potent in growing tissue, such as breast and the uterus.
While both are available in the form of oral tablets, vaginal creams, and suppositories, only estradiol is available as transdermal patches.
Nonetheless, to get the most out of estradiol without the side effects, doctors will typically recommend balancing your intake with estriol.
The Safest Alternative
The Safest Alternative
If you’re looking for the safest way to increase estrogen and you have no access to pharmaceutical options, there is another option: go the all-natural way.
There are specific types of food that can boost compounds that have the same effect as estrogen in your bloodstream. These estrogen boosters are rich in phytoestrogens, which are plant-derived estrogens that mimic the action of endogenous estrogen in your body. These include food such as soybeans, oats, and flaxseeds.
Other sources include supplements that make use of active ingredients sourced from plants such as Puerariamirifica. The phytoestrogens from P. mirifica will produce milder side effects, resulting in a safer yet effective estrogen supplement.
Estriol and estradiol help improve the quality of life in elderly women by relieving their various menopausal symptoms and reducing the risk of osteoporosis.
Estriol and estradiol help improve the quality of life in elderly women by relieving their various menopausal symptoms and reducing the risk of osteoporosis.
Conclusion
Conclusion
Estriol and estradiol help improve the quality of life in elderly women by relieving their various menopausal symptoms and reducing the risk of osteoporosis.
Natural alternatives are available as phytoestrogens in multiple dietary substances like soybeans and oats, as well as in the form of supplements derived from Puerariamirifica.
We recommend that you choose your treatment modality under the guidance of a licensed health care professional. Your doctor can help you sort out which hormone in the estriol vs estradiol matter would be better for your case, and even recommend you an optimal natural alternative!
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